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The study of brain lesions and their impact on cognition and behavior has been the dominant tool used to examine the complex function of the brain for the last three centuries. By testing neuropsychological deficits that correlate with a lesion in a particular part of the brain, it is possible to hypothesise about the role and cognitive function of that individual brain area. Over the past several decades, the rapid development and implementation of many new technologies to visualize brain activity has greatly augmented our understanding of brain function. However, even now there are many experimental questions that are difficult, if not impossible to answer in any way other than lesion techniques. Such studies though are not without their own challenges to overcome such as lesion-induced neuroplasticity, widespread degenerative changes, and the permanent nature of a lesion. Recent developments in different fields of neuroscience have provided tools to overcome many of the problems rel
This book investigates the methodological limitations of traditional permanent brain lesion studies and proposes reversible deactivation as a superior alternative for mapping cortical function. Authors Ralf Galuske and Stephen Lomber synthesize decades of neuroscientific research to address how researchers can isolate specific brain regions without the confounding variables of neuroplasticity or permanent tissue damage. The text provides a rigorous framework for understanding how temporary inactivation techniques allow for more precise mapping of cognitive and behavioral processes in the mammalian brain.
What You Will Find
Experts in the field of systems neuroscience recognize this work as a critical reference for researchers seeking to refine their experimental designs. Readers frequently note the technical density of the prose, which is intended for an audience of advanced students and professional neuroscientists.
Page Count:
392
Publication Date:
2002-11-07
Publisher:
Oxford University Press
ISBN-10:
019850893X
ISBN-13:
9780198508939
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