A young boy faces the harsh realities of poverty and displacement during the Christmas season. The story follows a boy named Samuel who, along with his pregnant mother, seeks shelter on Christmas Eve. They are turned away from multiple homes, mirroring the biblical story of the Nativity, and must confront the indifference of the world as they search for a place to stay. The narrative explores themes of compassion, faith, and the true meaning of Christmas through Samuel's innocent yet profound experiences.

The collection is appreciated for its heartwarming and thought-provoking narratives that capture the essence of the Christmas spirit. Readers often highlight the poignant storytelling and the way Paterson imbues each story with a sense of hope, even amidst hardship. The titular story, 'No Room in the Inn,' is frequently cited for its powerful message and its ability to resonate with the traditional Christmas narrative. The overall sentiment suggests a collection that offers both comfort and reflection, making it a fitting read for the holiday season.