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Oral bioavailability is a critical parameter in drug development, influencing the efficacy and safety of therapeutic agents. This book provides a comprehensive overview of the factors that determine oral bioavailability, including drug properties, formulation strategies, and physiological barriers. It covers essential topics such as drug solubility, permeability, first-pass metabolism, and the impact of food and drug interactions. The text also explores advanced concepts like pharmacokinetic modeling and strategies for overcoming poor oral bioavailability, making it an indispensable resource for researchers, formulators, and regulatory scientists in the pharmaceutical industry.
This book investigates the complex factors governing the absorption of orally administered drugs. It delves into the physiological and physicochemical barriers that limit drug entry into the bloodstream, exploring how formulation, drug properties, and biological variability influence bioavailability. The work aims to provide a comprehensive understanding of the principles and challenges associated with achieving effective oral drug delivery.
This text is recognized as a detailed and authoritative resource for professionals and researchers in pharmaceutical sciences. Its comprehensive coverage of biopharmaceutic principles and practical considerations makes it a valuable reference for understanding and improving oral drug delivery. The book is noted for its rigorous scientific approach and its utility in drug development and formulation.
Page Count:
540
Publication Date:
2011-01-01
ISBN-10:
0470260998
ISBN-13:
9780470260999
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