A catastrophic viral outbreak transforms the population of London into mindless, rage-filled predators, forcing disparate survivors to navigate a collapsing society. The narrative follows multiple perspectives, including the scientists responsible for the initial contagion and individuals fighting for survival in the immediate aftermath. These characters must contend with both the physical threat of the infected and the breakdown of social order. The story employs a multi-threaded structure that bridges the gap between the original film and its sequel, utilizing a visual medium to emphasize the visceral nature of the infection.

This graphic novel serves as a bridge for fans of the film franchise, expanding on the lore of the Rage Virus through a series of interconnected vignettes. The work is characterized by its bleak tone and focus on the rapid collapse of civilization, which aligns with the established aesthetic of the source material. Readers often note the effectiveness of the visual storytelling in capturing the frantic energy of the infected. The narrative succeeds in providing context for the events leading into the sequel, maintaining a consistent atmosphere of dread throughout the collection.