The book investigates the complex life of Stuart Shorter, a man whose existence was marked by crime, mental health struggles, and a unique narrative perspective. Alexander Masters chronicles his friendship with Shorter, a man who defied conventional categorization, exploring the societal and personal forces that shaped his trajectory from childhood to a tragic end. The narrative structure, conceived by Shorter himself, unfolds in reverse chronological order, beginning with his death and culminating in his early years.

Stuart: A Life Backwards was widely acclaimed upon its release, earning the Guardian First Book Award and being recognized for its innovative approach to biography. Critics lauded its compelling narrative, humane portrayal, and unexpected humor, noting how it expanded the possibilities of the genre. The book's unique structure and its focus on a complex, often marginalized individual resonated with readers and reviewers alike. It is considered an extraordinary and unexpected account of a remarkable life.