This text investigates the technical application and methodological utility of neutron protein crystallography (NPC) in resolving structural details of biological macromolecules that are invisible to X-ray techniques. Nobuo Niimura and Alberto Podjarny, both established researchers in the field, synthesize current experimental protocols and theoretical frameworks to explain how neutron diffraction provides unique insights into hydrogen positioning and hydration states. The book serves as a comprehensive guide for structural biologists seeking to utilize neutron sources for high-resolution protein analysis.

Experts identify this work as a foundational technical reference for researchers entering the specialized field of neutron crystallography. Readers frequently note the high level of technical density, making it a primary resource for advanced graduate students and professional structural biologists.