This text investigates the fundamental principles of human physiology and their application to clinical medical practice. Samson Wright, a distinguished physiologist, established a framework that integrates basic biological mechanisms with the functional requirements of the human body. This edition, updated by Cyril A. Keele and other contributors, synthesizes decades of physiological research into a comprehensive reference for medical students and practitioners.

Experts recognize this work as a foundational text in the history of medical education, noted for its clear prose and logical organization. Readers frequently highlight the academic density of the content, which remains a standard reference for understanding the evolution of physiological teaching methods.