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Significant advances in metal-catalyzed reactions, especially cyclizations, have dramatically improved the efficiency of organic synthesis over the last three decades. To date these transformations are widely used in the area of synthesis of both natural products and therapeutic agents. "Science of Synthesis: Metal-Catalyzed Cyclization Reactions" presents the most commonly used and significant metal-catalyzed reactions for modern organic synthesis. The basic principles, the current state of the art, scope, limitations, and mechanism of these reactions are also discussed. Typical examples of target synthesis are provided to help inspire further applications. Volume 2 covers epoxidations, aziridinations, cyclopropanations, and Pauson-Khand reactions, as well as a wide range of cycloaddition processes, radical cyclizations, and ring-closing metathesis.
This volume details critical metal-catalyzed cyclization reactions essential for modern organic synthesis. It focuses on advancements made over the last three decades, highlighting their efficiency in creating natural products and therapeutic agents. The book covers fundamental principles, current methodologies, reaction scope, limitations, and mechanisms, supported by illustrative examples for practical application.
This volume is part of the 'Science of Synthesis' series, which is recognized for its comprehensive and authoritative coverage of synthetic organic chemistry. The series aims to provide chemists with detailed information on the most important synthetic methodologies, making it a valuable resource for both academic research and industrial applications. The focus on metal-catalyzed cyclizations in this volume addresses a key area of modern synthesis, offering practical insights and examples for practitioners.
Page Count:
766
Publication Date:
2016-12-14
Publisher:
Thieme Medical Publishers Inc.
ISBN-10:
3131998512
ISBN-13:
9783131998514
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