This book constitutes the refereed proceedings of the 6th EAI International Conference on Smart Grid and Internet of Things, SGIoT 2022, held in TaiChung, Taiwan, in November 19-20, 2022. The 33 regular papers presented were carefully reviewed and selected from 96 submissions. The papers cover a broad range of topics in wireless sensor, vehicular ad hoc networks, security, deep learning and big data. The papers are organized in subject areas as follows: IoT, Communication Security, Data Mining or Big Data; Artificial Intelligence, Machine Leaning, Deep Learning and Neural Network; WLAN, Wireless Internet and 5G; Protocol, Algorithm, Services and Applications.