This volume investigates the current state and historical progression of nuclear magnetic resonance (NMR) spectroscopy as a primary tool for determining protein structure. Edited by John L. Markley and Stanley J. Opella, the text compiles contributions from leading researchers in the field to honor the work of pioneer Oleg Jardetsky. It provides a comprehensive overview of the technology's evolution, ranging from fundamental principles to advanced clinical and in vivo applications.

Experts recognize this work as a foundational reference for researchers and students engaged in structural biology. Readers frequently note the technical density of the prose, which reflects the high level of expertise contributed by the field's leading investigators.