
This scholarly volume distills the current understanding of cell-to-cell contact mediated by molecules generated within the cellular compartments and shuttled between them or exported. The examination of these vital processes begins by focusing on the receptor function of platelets, which involves a set of membrane glycoproteins that provides sites for binding of adhesive macromolecules, such as von Willebrand factor and fibrinogen, and for assembly of clotting factors. The second section explores metabolism of arachidonic acid by the platelets and vessel walls. The ongoing interplay among platelets, plasma factors, and the vessel wall--the central problem of hemostasis--is analyzed in the final section.
This volume investigates the complex molecular mechanisms governing the interaction between platelets and the vessel wall during the process of hemostasis. The authors, Jacek J. Hawiger, John A. Oates, and Russell Ross, synthesize research regarding cellular communication, membrane glycoprotein function, and metabolic pathways to provide a comprehensive framework for understanding how these components maintain vascular integrity and respond to injury.
What You Will Find
Experts recognize this work as a technical resource for researchers and clinicians specializing in vascular physiology and hematology. Readers frequently note the academic density of the prose, which is intended for those with a strong background in cellular biology and clinical medicine.
Page Count:
180
Publication Date:
1988-02-18
Publisher:
Oxford University Press
ISBN-10:
0195206886
ISBN-13:
9780195206883
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