The conquest of New Granada details the Spanish subjugation of the Muisca people and the establishment of colonial rule in the region that is now Colombia. Sir Clements R. Markham, a noted geographer and historian, draws upon primary sources and historical accounts to reconstruct the events of this pivotal period. The narrative focuses on the military campaigns, political maneuvering, and cultural clashes that defined the Spanish conquest, exploring the motivations of the conquistadors and the impact on the indigenous populations. Markham's work provides a comprehensive examination of the complex historical forces at play during this era of profound transformation.

Sir Clements R. Markham's "The Conquest of New Granada" is recognized as a significant historical study of the Spanish colonization of the Muisca territory. Scholars often cite Markham's meticulous research and reliance on primary sources as strengths of the work. The book is valued for its detailed narrative of the military and political events, offering a comprehensive overview of the period. While some historical interpretations may have evolved since its original publication, it remains a foundational text for understanding this critical chapter in South American history.