
Microsatellites are short stretches of repeated DNA that show exceptional variability in humans and most other species. This variability has made microsatellites the genetic marker of choice for numerous applications, including genetic mapping and studies of evolutionary connections between species and populations. This book details the molecular processes which give rise to microsatellite DNA and then describes the wide range of applications in medical genetics, forensics, the study of human evolution, and conservation genetics. Drawing from an international group of researchers, the book presents the theoretical background and the hands-on details for many of the popular analytic methods using microsatellites, including methods for estimating coalescent times, population divergences, and migration.
This book investigates the molecular mechanisms driving microsatellite variability and evaluates their utility as genetic markers across diverse biological disciplines. Editors Christian Schlotterer and David B. Goldstein compile contributions from an international cohort of researchers to establish a comprehensive framework for understanding these repetitive DNA sequences. The text synthesizes theoretical models of mutation with practical methodologies for applying microsatellite data to complex genetic inquiries.
What You Will Find
Experts recognize this volume as a foundational reference for researchers utilizing microsatellite markers in population genetics. Readers frequently note the technical density of the prose, which assumes a solid background in molecular biology and statistical analysis.
Page Count:
368
Publication Date:
1999-09-16
Publisher:
Oxford University Press
ISBN-10:
0198504071
ISBN-13:
9780198504078
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