The resistance to systemic therapy in breast cancer presents a critical clinical challenge. This book, authored by leading experts, delves into the multifaceted problem of chemosensitivity in breast cancer. It progresses from a clinical overview to detailed explorations of molecular mechanisms underlying drug resistance, including multidrug resistance proteins, apoptosis evasion, cell cycle and DNA repair deregulation, and the roles of tumor suppressors and growth factors. The text also highlights novel approaches aimed at sensitizing breast cancer cells to treatment, offering insights into future therapeutic strategies.

This compilation of expert reviews addresses the complex issue of breast cancer chemosensitivity, focusing on the molecular underpinnings of treatment resistance. The scope covers a wide array of resistance mechanisms, from protein pumps to genetic and signaling pathway alterations. The inclusion of novel chemosensitization strategies suggests a forward-looking perspective on therapeutic development. The book is structured to provide both a clinical context and detailed scientific insights for researchers and clinicians in the field.