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Successful transplantation depends on the minimization of immunological differences between the donor and recipient tissues. These differences are based on polymorphisms of the human major histocompatibility complex and play a major role in determining the acceptance or rejection of allograftsduring transplantation. Histocompatibility Testing: A Practical Approach describes methods for the investigation of these polymorphisms at the gene and protein levels and their application to the clinical transplanation of human organs and bone marrow. There is currently no other text available covering these up-to-dateserological and molecular techniques in this area of immunogenetics, despite their importance to fundamental research, clinical practice and forensic medicine. This book will therefore be of great interest to researchers in many subject areas, irrespective of whether they are in establishedlaboratories or are entering this field for the first time.
This text investigates the critical role of human major histocompatibility complex polymorphisms in determining the success or failure of organ and bone marrow transplantation. Authors Derek Middleton and Philip Dyer provide a comprehensive technical framework for analyzing these immunological differences at both the gene and protein levels. The book serves as a primary reference for laboratory professionals and researchers, synthesizing complex serological and molecular techniques into a standardized clinical methodology.
What You Will Find
Experts identify this work as a foundational technical resource for practitioners in the field of immunogenetics. Readers frequently note the high level of procedural detail, which makes it a standard reference for laboratory-based histocompatibility testing.
Page Count:
326
Publication Date:
1993-07-08
Publisher:
Oxford University Press
ISBN-10:
0199633649
ISBN-13:
9780199633647
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