Author Description

This volume addresses one of the fundamental problems of cell biology--how proteins are sent to and maintained at their correct destinations within cells. Some general themes include the targeting sequences that act as "molecular tags," the receptors that recognize them, and the role of molecular chaperones. Other chapters focus on how proteins are targeted to organelles that communicate with one another during membrane trafficking in the secretory and endocytic pathways. The book is extensively referenced and provides an up-to-date review of the research in an area that has applications for understanding cancer, studying diseases that result from faulty targeting, and genetic manipulation of microorganisms to target useful proteins.