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Pore-forming proteins and peptides play a central role in bacterial pathogenesis, the immune response, venomous attack, and innate immunity. Pore-forming Peptides and Protein Toxins describes how natural and synthetic peptides and toxins form pores and ionic channels that cause cell membrane collapse and cell death. Written by researchers from around the world, it discusses such topics as the channel-forming properties of Helicobacter pylori and the role of amyloid peptide channels in the development of amyloid diseases. This text provides a multidisciplinary approach to understanding the basic principles and cellular mechanisms of the actions of toxins and their potential use as research tools.
This volume investigates the fundamental biophysical and molecular mechanisms by which pore-forming peptides and protein toxins disrupt cellular integrity to induce cell death. The text compiles research from an international cohort of scientists to examine how these agents function across diverse biological contexts, including bacterial pathogenesis, immune responses, and the progression of amyloid-related diseases. By integrating perspectives from structural biology and toxicology, the work establishes a framework for understanding both the destructive potential of these toxins and their utility as specialized research tools.
What You Will Find
Experts identify this volume as a specialized reference for researchers and graduate students working in the fields of membrane biology and toxicology. Readers frequently note the technical density of the prose, which serves as a foundational resource for understanding the complex interactions between protein toxins and cellular structures.
Page Count:
360
Publication Date:
2003-01-01
Publisher:
CRC Press
ISBN-10:
0203986644
ISBN-13:
9780203986646
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