This volume presents the proceedings of the 12th International Symposium on Bioinformatics Research and Applications (ISBRA 2016). The symposium, held in Minsk, Belarus, from June 5-8, 2016, gathered researchers to discuss advancements in bioinformatics. The 25 selected papers, chosen from 77 submissions, cover critical areas such as next-generation sequencing data analysis, protein-protein interactions and networks, protein and RNA structure, phylogenetics, sequence analysis, and statistical methods, reflecting the latest research in the field.

As a collection of research papers from an international symposium, this volume is intended for specialists in the field of bioinformatics. The inclusion of peer-reviewed submissions suggests a focus on rigorous scientific methodology and novel findings. The organization into specific topical sections indicates a structured approach to presenting current research challenges and solutions within bioinformatics.