This encyclopedia serves as a comprehensive reference work designed to synthesize the complex historical, cultural, and archaeological record of Mesoamerica from the pre-Columbian era to the modern day. Edited by David Carrasco, a prominent scholar in the study of religions and Mesoamerican cultures, the work aggregates contributions from leading experts across multiple disciplines. It provides a structured framework for understanding the continuity and transformation of civilizations spanning from Mexico to Central America, utilizing a cross-referenced format to facilitate academic inquiry.

Scholars and students frequently identify this work as a foundational reference text for the study of Mesoamerican history and anthropology. The academic rigor and breadth of the entries make it a standard resource for those requiring detailed, peer-reviewed information on the region.