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Drugs like Lipitor, Plavix, Taxol, and Zoloft are integral in today's medicinal world. These widely used products save lives and improve the quality of lives, playing a crucial role in everything from cholesterol management to cancer treatment. These advances in medicine were brought into existence after nuanced process of creation, featuring a wide range of chemical and pharmacological experimentation and discovery.Top Drugs: Their History, Pharmacology, and Synthesis provides an in-depth study on ten prominent drugs, outlining the chemistry behind each one's creation. Jie Jack Li, a medicinal chemist and an expert on drug discovery, offers a thorough analysis of the landscape of current drug development. The comprehensive text is divided by health issues, including cardiovascular, cancer, metabolic diseases, and infectious diseases. Each section features individual chapters on significant drugs, outlining the chemistry and history of the drug's discovery. Li begins each chapter with the product's history, providing necessary context. Li then proceeds to describe the mechanism of action, structure-activity relationship (SAR), bioavailability, metabolism, toxicology, the discovery route, and the process route. Top Drugs: Their History, Pharmacology, and Synthesis will acclimate students, scientists, and interested laypersons to the world of chemistry and drug discovery.
This book investigates the chemical origins, pharmacological mechanisms, and historical development of ten of the most significant pharmaceutical products in modern medicine. Author Jie Jack Li, a medicinal chemist with extensive experience in drug discovery, utilizes his technical background to bridge the gap between clinical application and laboratory synthesis. He presents a structured framework that examines how specific chemical structures translate into therapeutic outcomes, providing a detailed look at the life cycle of life-saving medications from initial discovery to commercial production.
What You Will Find
Experts and academics recognize this text as a valuable resource for students and professionals seeking to understand the intersection of organic chemistry and drug development. Readers frequently note the technical density of the prose, which effectively balances historical narrative with rigorous scientific methodology.
Page Count:
218
Publication Date:
2015-01-01
Publisher:
Oxford University Press
ISBN-10:
0199362602
ISBN-13:
9780199362608
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