This text investigates the complex interplay between pharmacological properties of psychoactive substances and the social, legal, and behavioral frameworks that define their use in contemporary society. Charles F. Levinthal, a professor of psychology, utilizes a multidisciplinary approach to synthesize biological, psychological, and sociological data. The book argues that understanding drug use requires a comprehensive analysis that moves beyond simple prohibitionist models to examine the systemic factors influencing human behavior and public health policy.

Experts frequently cite this text as a foundational resource for undergraduate courses in psychology and sociology due to its balanced, evidence-based approach. Readers often note the academic density of the prose, which provides a rigorous overview of complex pharmacological and social issues without sacrificing clarity.