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This book discusses the development of various reliable scanning electrochemical microscopy (SECM) imaging techniques for studying the distribution of biomarkers and nanomaterials in thin and thick animal samples, plant antioxidant (AO) defense systems, as well as human melanoma. The authors demonstrate that SECM could improve the diagnosis and understanding of different melanoma stages on the basis of highly resolved maps of the tyrosinase distribution. Tyrosinase is the key enzyme involved in fruit maturation and is a biomarker for melanoma. As such the book presents various tyrosinase SECM detection strategies developed for the analysis of the spatial distribution of tyrosinase in melanoma and in banana samples. It describes the first imaging of the redox active proteins within the entire mouse heart with an SECM system using a spider probe composed of eight independent microelectrodes. Further, it investigates distributions of injected graphene nanoribbons (GONRs) for drug deliveryby Soft-Probe-SECM. Lastly, the book outlines a non-invasive electrochemical strategy for mapping the AO activity of apple peel using Soft-Probe-SECM.
This book details the development of advanced scanning electrochemical microscopy (SECM) techniques for high-resolution imaging of biological samples. The author, Tzu-En Lin, presents novel SECM imaging methods applicable to diverse biological systems, including animal tissue, plant defense mechanisms, and human melanoma. The research demonstrates SECM's potential in improving diagnostic accuracy by mapping critical biomarkers like tyrosinase, an enzyme relevant to both fruit maturation and melanoma progression. The book further explores the application of SECM in visualizing injected nanomaterials for drug delivery and assessing antioxidant activity in plant tissues.
The book presents a detailed exploration of Soft-Probe-SECM techniques, highlighting their utility in biological imaging and diagnostics. The research showcases the application of these methods across various biological systems, from animal tissues to plant and human samples. The focus on tyrosinase distribution in melanoma and fruit samples, as well as protein imaging in mouse hearts, suggests a strong emphasis on practical, high-resolution mapping capabilities. The inclusion of nanomaterial tracking and antioxidant activity assessment further broadens the scope of its potential applications in scientific research and medical diagnosis.
Page Count:
120
Publication Date:
2019-01-12
Publisher:
Springer International Publishing
ISBN-10:
3030057577
ISBN-13:
9783030057572
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