Driven by an internal sense of existential dissatisfaction, Eugene Henderson, a wealthy American millionaire, abandons his life in Connecticut to seek meaning in the remote regions of Africa.

Upon arriving in Africa, Henderson encounters two distinct tribes, the Arnewi and the Wariri, whose cultural practices and spiritual beliefs challenge his Western perspective. He attempts to integrate himself into these societies, often causing disruption through his impulsive nature and physical stature. The narrative framework follows a first-person perspective, capturing Henderson's internal monologue as he grapples with his own identity and the absurdity of his situation. His primary opposition is not a singular antagonist, but rather his own restlessness and the cultural misunderstandings that arise from his presence in a foreign land.

Readers and critics frequently highlight the novel's exuberant prose and the distinct, often chaotic voice of its protagonist. Discussion often centers on the balance between the comedic elements of Henderson's blundering and the deeper, more somber philosophical questions regarding the human condition. Many observers note that the world-building serves primarily as a mirror for Henderson's internal state rather than a realistic depiction of African geography or culture. The pacing is often described as episodic, reflecting the erratic nature of the protagonist's search for self-actualization. Readers generally agree that the work functions as a complex character study that avoids simple moral conclusions.