This text investigates the most significant unresolved questions within the field of systems neuroscience by soliciting expert perspectives on the fundamental mechanisms of brain function and behavior. Editors J. Leo van Hemmen and Terrence J. Sejnowski, both established figures in computational neuroscience, curate a collection of essays from 23 leading researchers. The book functions as a structured inquiry into the current state of brain science, utilizing a multi-disciplinary framework that spans from evolutionary biology to the philosophy of qualia.

Experts recognize this volume as a valuable roadmap for researchers and students seeking to understand the current frontiers of systems neuroscience. Readers frequently note the academic density of the prose, which is intended for those already familiar with the foundational concepts of computational biology.