The arrival of the enigmatic Humphry Clinker into Squire Bramble's household acts as the catalyst for a series of misadventures during a tour of Britain. The narrative follows the members of the Bramble family as they navigate social absurdities, failed romances, and physical mishaps across the country. Each character pursues their own personal objectives, often clashing with the rigid social expectations of the 18th century. The story is presented through an epistolary framework, allowing the reader to observe how the same events are interpreted through the distinct, often conflicting, perspectives of the various letter writers.

Discussion often centers on the effectiveness of the epistolary format in highlighting the subjective nature of truth and character perception. Readers frequently highlight the contrast between the grumpy, cynical tone of Squire Bramble and the more optimistic or naive outlooks of his companions. Critics often note that the novel serves as a culmination of Smollett's stylistic evolution, blending his medical expertise with a sharp, observational wit. The balance between the episodic nature of the travelogue and the development of the core cast remains a frequent point of analysis for those studying 18th-century satire. Many readers find the humor remains accessible despite the archaic language, appreciating the vivid portrayal of the era's social landscape.